[HTML][HTML] Pluripotent stem cell-derived cardiomyocytes as a platform for cell therapy applications: progress and hurdles for clinical translation

A Oikonomopoulos, T Kitani, JC Wu - Molecular Therapy, 2018 - cell.com
therapy has been applied to restore lost cardiac muscle and cardiac performance. Induced
pluripotent stem cells … from pre-clinical studies, progress toward clinical applications has been …

Preclinical studies of stem cell therapy for heart disease

BA Tompkins, W Balkan, J Winkler… - Circulation …, 2018 - Am Heart Assoc
stem cell therapies for cardiovascular disease. The quality of this research has improved
over the past 10 to 15 years and overall indicates that cell therapy … not necessarily translate to …

[HTML][HTML] Mesenchymal stem cell-based therapy for cardiovascular disease: progress and challenges

L Bagno, KE Hatzistergos, W Balkan, JM Hare - Molecular Therapy, 2018 - cell.com
… While these improvements demonstrate the potential of stem cell therapy, the goal of full …
this goal, novel cell-based therapeutic approaches are needed. Ongoing studies include cell

Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
… , led to the rapid translation of SC therapies within the same year [4… and so far, no cell therapy
has been unambiguously shown … stem and progenitor cells towards a cardiomyogenic fate …

Exosomes generated from iPSC-derivatives: new direction for stem cell therapy in human heart diseases

JH Jung, X Fu, PC Yang - Circulation research, 2017 - Am Heart Assoc
Cardiovascular disease (CVD) is the leading cause of death in … ), which may contribute toward
unique therapeutic potentials of … to translate the enormous potential of pluripotent stem cell

[HTML][HTML] Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types

E Cambria, FS Pasqualini, P Wolint, J Günter… - NPJ Regenerative …, 2017 - nature.com
… the translation of first-generation and second-generation cell types. … obtained by the
TOPCARE-CHD trial, where intracoronary … , such as MSCs and pluripotent stem cells, toward

Concise review: rational use of mesenchymal stem cells in the treatment of ischemic heart disease

MR Ward, A Abadeh, KA Connelly - Stem cells translational …, 2018 - academic.oup.com
… This review will focus upon a well-studied and safe stem cell subpopulation known as
mesenchymal stem cells (MSCs). We will further focus upon the use of MSCs as a therapeutic

[HTML][HTML] Regenerative medicine therapy for single ventricle congenital heart disease

C Ambastha, GJ Bittle, D Morales… - Translational …, 2018 - ncbi.nlm.nih.gov
… and other forms of CHD. This article reviews the many stem cell types applied to CHD, their
Stem Cell Therapy for CHD: Towards Translation. Cardiol Young 2015;25:58-66. HLHS, …

Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell-Derived Blood CellsReady for Take-Off

K Haake, M Ackermann… - Stem cells translational …, 2019 - academic.oup.com
… efforts to translate iPSC-derived blood cells toward clinical use, with the main focus on
hematopoietic stem cells (… The clinical translation of induced pluripotent stem cell (iPSC)-derived …

Clinical studies of cell therapy in cardiovascular medicine: recent developments and future directions

MN Banerjee, R Bolli, JM Hare - Circulation research, 2018 - Am Heart Assoc
Translation to clinical trials has almost outpaced our … likely play a large role in stem cell
efficacy. Therefore, careful analysis … research on cell-based therapies for cardiovascular disease, …